Mushroom-based supplements have gone from niche wellness products to mainstream staples.  

Backed by research into functional mushrooms like lion’s mane, reishi, cordyceps, and chaga, these blends are marketed for a range of benefits, from sharper focus to reduced stress. 

Two brands stand out in this space: AEON ONE™, a comprehensive daily superblend from True Aeon, and Four Sigmatic, best known for its mushroom coffees and targeted capsule blends. 

Both promise to support focus and stress relief, but they take different approaches: AEON ONE™ as a broad-spectrum daily foundation, Four Sigmatic as a targeted mushroom specialist. So, which is better for your needs? 

Why Mushrooms and Adaptogens Are Linked to Focus and Stress Relief 

Lion’s Mane for Neuroplasticity 

Lion’s mane mushroom (Hericium erinaceus) has been studied for its potential to stimulate nerve growth factor (NGF), a protein that supports brain plasticity.  

Small clinical trials suggest it may improve memory and focus over weeks of consistent use [PMID: 38004235].  

Reishi for Stress Balance 

Reishi (Ganoderma lucidum) is often called the “mushroom of immortality” in traditional medicine.  

Modern studies highlight its adaptogenic properties, helping regulate stress responses and promote calmness, although much of the evidence remains preliminary. 

Adaptogens for Cortisol Regulation 

Herbs like ashwagandha and rhodiola are often paired with mushrooms to enhance resilience. 

• Ashwagandha has shown consistent cortisol-lowering effects in human trials [PMID: 31517876].  
• Rhodiola may reduce fatigue and improve cognitive performance under stress [PMID: 35745023].  

The Gut-Brain Axis 

Emerging research shows probiotics and digestive health influence mood, stress, and cognition [PMID: 31043907].  

While mushrooms and adaptogens directly modulate stress pathways, gut health complements them by stabilizing neurotransmitter production and nutrient absorption. 

Four Sigmatic: Targeted Mushroom & Adaptogen Blends 

Brand Philosophy 

Four Sigmatic has built its reputation around functional mushrooms for everyday wellness. 

Unlike brands that position themselves as all-in-one solutions, Four Sigmatic emphasizes targeted support.  

Each product is carefully formulated with a small set of ingredients designed for a specific benefit: focus, calm, immunity, or energy. 

The company highlights its sourcing standards -organic mushrooms, rigorous third-party testing, and a focus on effective doses rather than “fairy dusting,” making it especially popular with wellness purists who care about transparency. 

Product Lineup 

1. Focus Capsules 

• Key ingredients: Lion’s mane, Bacopa monnieri, and Rhodiola rosea. 
• Intended benefits: Enhanced mental clarity, improved memory, and resilience against mental fatigue. 
• How it works: 
  • Lion’s mane supports neuroplasticity and nerve growth factor (NGF). 
  • Bacopa is an Ayurvedic herb studied for memory and learning improvements. 
  • Rhodiola is an adaptogen that helps the body manage physical and mental stress. 

This formula is ideal for professionals, students, or creatives who want a sharper focus without caffeine. 

2. Calm Capsules 

• Key ingredients: Reishi mushroom and Ashwagandha root. 
• Intended benefits: Stress reduction, better sleep quality, and a calmer mood. 
• How it works: 
  • Reishi is known as the “queen of mushrooms” for its balancing, calming properties. 
  • Ashwagandha has human clinical trial evidence for reducing cortisol and anxiety symptoms. 

This blend is often taken in the evening to support relaxation and recovery from daily stress. 

3. Mushroom Coffees & Elixirs 

• Key blends: Coffee infused with Lion’s Mane (for focus), Chaga (for antioxidants), and sometimes Cordyceps (for stamina). 
• Intended benefits: A smoother coffee experience -energy without the jittery crash. 
• Unique appeal: It combines the daily ritual of coffee with the functional benefits of mushrooms, making it easy to adopt. 

4. Energy & Immunity Products 

• Cordyceps Elixir: Marketed for athletic performance and stamina. 
• Chaga Elixir: Marketed for antioxidant support and immunity. 
• These single-focus elixirs let users pick a formula based on their specific health goals. 

Format & Accessibility 

Four Sigmatic’s strength lies in variety and accessibility. Unlike AEON ONE™, which is a single powder, Four Sigmatic offers: 

• Capsules for convenience. 
• Elixir packets for mixing with water or smoothies. 
• Coffee blends for those who don’t want to give up their morning brew. 

This flexibility makes Four Sigmatic appealing to people who want to add mushrooms and adaptogens into existing routines rather than adopting an entirely new ritual. 

Price & Value 

• Most Four Sigmatic supplements cost between $10–$300 depending on the product or kit. 
• This makes them more affordable upfront compared to AEON ONE™. 
• However, since each product targets a single benefit, users may need to buy multiple formulas (Focus + Calm + Immunity) if they want broader coverage -which can quickly add up. 

Who Four Sigmatic Appeals To 

• Coffee drinkers who want to enhance their morning ritual with mushrooms. 
• Busy professionals who want simple capsules for specific goals like focus or stress relief. 
• Budget-conscious users who prefer starting with one affordable, targeted supplement. 
• Mushroom enthusiasts who want product-specific blends rather than a one-size-fits-all formula. 

AEON ONE™: A Comprehensive Whole-Food Superblend 

Brand Philosophy 

While many supplement companies focus on single benefits or small ingredient stacks, AEON ONE™ takes a different approach.  

Developed by TrueAeon, it’s marketed as “Made by nature, not in a lab.” This means the product is built entirely around whole-food ingredients, with no synthetic isolates or artificial fillers. 

The philosophy is simple: instead of juggling multiple products, a mushroom powder here, a probiotic there, an adaptogen capsule elsewhere -AEON ONE™ combines everything into one superblend that covers multiple aspects of health and wellness. 

It’s positioned not just as a greens powder, but as a comprehensive daily ritual for energy, focus, gut health, stress balance, and long-term resilience. 

Ingredient Diversity 

One of AEON ONE™’s strongest selling points is its ingredient diversity.  

Where Four Sigmatic typically delivers 3-5 core ingredients per formula, AEON ONE™ includes over 50+ whole-food components across several categories: 

• Red & Purple Fruits: Beetroot, dragon fruit, berries, pomegranate, acerola cherry, noni, purple carrot rich in polyphenols and antioxidants that support cellular energy and recovery. 
• Greens & Vegetables: Spinach, spirulina, chlorella, broccoli, wheatgrass, barley grass, moringa, green apple delivering chlorophyll, vitamins, and minerals for daily vitality. 
• Yellow & Orange Fruits: Mango, citrus, pineapple, papaya, turmeric for carotenoids, digestive enzymes, and anti-inflammatory support. 
• Adaptogens & Mushrooms: Ashwagandha, rhodiola, maca, ginseng, plus lion’s mane, reishi, cordyceps, chaga, shiitake, maitake, turkey tail, agaricus blazei, a broad stack for cognitive support, immune resilience, and stress balance. 
• Gut & Hydration: Coconut water, Himalayan pink salt, probiotics (Bacillus coagulans), digestive enzymes helping to maintain microbiome balance and electrolyte hydration. 
• Other Boosts: Monk fruit (natural sweetness), ginger, sea buckthorn, shilajit, providing extra minerals, phytonutrients, and adaptogenic effects. 

This blend means AEON ONE™ isn’t limited to one health angle. It’s designed to act as a nutritional foundation, touching multiple systems at once. 

Mushroom Support 

Like Four Sigmatic, AEON ONE™ features functional mushrooms -but it casts a wider net: 

• Lion’s Mane: Cognitive support and focus. 
• Reishi: Stress balance and immune modulation. 
• Cordyceps: Oxygen efficiency and endurance. 
• Chaga: Antioxidant powerhouse. 
• Shiitake, Maitake, Turkey Tail, Agaricus Blazei: Broader immune and metabolic support. 

Instead of picking one mushroom for one benefit, AEON ONE™ combines multiple mushrooms, offering a broader approach. 

Adaptogen Support 

AEON ONE™ also integrates several clinically studied adaptogens: 

• Ashwagandha: Shown to lower cortisol and support calm focus. 
• Rhodiola: Associated with reduced fatigue and enhanced stress resilience. 
• Maca: Traditionally used for endurance and vitality. 
• Ginseng: Long used for stamina and cognitive performance. 

By pairing these with mushrooms, AEON ONE™ goes beyond the scope of most mushroom blends, addressing both mental and physical resilience. 

Gut & Hydration Benefits 

Unlike Four Sigmatic, AEON ONE™ incorporates probiotics, digestive enzymes, coconut water, and Himalayan pink salt. This means it not only delivers mushrooms and adaptogens but also helps: 

• Improve digestion and nutrient absorption. 
• Support the gut-brain axis (where much of our serotonin is produced). 
• Maintain electrolyte balance for daily hydration. 

This makes AEON ONE™ particularly appealing for those who want digestive and gut health support built in. 

Taste & Format 

• Format: Powder form (30 servings per tub). 
• Flavor: Fruity and berry-forward, with subtle earthy undertones from the greens and mushrooms. 
• Mixability: Can be blended into smoothies, shakes, or simply stirred into water. 

This makes it more versatile than capsules or coffees. Instead of taking multiple pills, users can fold AEON ONE™ into their daily hydration or nutrition rituals. 

Price & Value 

• Price: $119.95 (regular) or $89.95 (sale). 
• Cost per serving: $3.00 (at sale price). 

While this makes AEON ONE™ more expensive than single-focus products like Four Sigmatic’s capsules, the value proposition is different. AEON ONE™ is meant to replace multiple supplements -greens powders, mushroom blends, adaptogen capsules, probiotics, and electrolyte mixes. 

When seen in this light, it can be more cost-effective for someone who would otherwise buy those separately. 

Who AEON ONE™ Appeals To 

• Holistic wellness users: Those who want one daily ritual to cover energy, focus, gut health, stress balance, and resilience. 
• Caffeine-free seekers: People looking for energy support without stimulants. 
• Simplifiers: Individuals who want to consolidate multiple supplements into one. 
• Long-term health optimizers: Users who prioritize resilience, immunity, and performance over quick fixes. 

Side-by-Side Comparison: AEON ONE™ vs Four Sigmatic 

At the time of review (September 2025), the retail price on the brand’s official site was $119.95 ($89.95 on sale) for 30 servings of AEON ONE™ (TrueAeon.com, accessed Sept 30, 2025). 

At the time of review (September 2025), Typical retail prices for Four Sigmatic ranged from $10–$300, depending on product (FourSigmatic.com).

Supplement Safety Reminder 

Supplement claims are not evaluated by the FDA the same way drugs are. Both established and newer brands have faced regulatory scrutiny for overstated claims. Always read the Supplement Facts label, look for third-party testing, and consult a healthcare professional before use. 

What the Science Says 

• Lion’s Mane: Small RCTs suggest improvements in cognition and memory with daily use. 
• Rhodiola: Evidence from human studies supports its role in reducing fatigue and enhancing mental performance under stress. 
• Ashwagandha: Multiple randomized controlled trials demonstrate reduced cortisol and stress levels. 
• Reishi: Traditionally used as a calming adaptogen. Modern research is still early, but supports immune and stress-modulating potential. 
• Probiotics (Unique to AEON ONE™): Clinical studies show probiotics like Bacillus coagulans may improve digestion and positively influence mood and stress via the gut-brain axis. 

Which Should You Choose? 

Deciding between AEON ONE™ and Four Sigmatic depends on your lifestyle, health goals, and budget. Both brands lean heavily on mushrooms and adaptogens, but they deliver them in very different ways. 

Choose Four Sigmatic if: 

• You want targeted support: Four Sigmatic products are designed for specific outcomes, such as Focus Capsules for concentration or Calm Capsules for stress. This makes them appealing if you only need one function addressed. 
• You prefer capsules or coffee: Not everyone enjoys mixing powders into water. Four Sigmatic offers capsules for convenience and mushroom coffee blends for people who want to keep their daily coffee ritual. 
• You are budget-conscious: At around 30 to 50 dollars per month for a single product, Four Sigmatic is more affordable than AEON ONE™. This makes it a good entry point if you want to explore mushroom supplementation without a large financial commitment. 
• You value flexibility: Because the formulas are targeted, you can pick and choose based on your needs. For example, you might take Focus Capsules during the day and Calm Capsules at night. 

Choose AEON ONE™ if: 

• You want a comprehensive solution: AEON ONE™ is designed as an all-in-one daily foundation. It includes mushrooms, adaptogens, fruits, greens, probiotics, enzymes, hydration support, and natural boosters in one scoop. 
• You want broad-spectrum focus and stress support: Instead of choosing between focus or calm, AEON ONE™ combines lion’s mane, reishi, cordyceps, rhodiola, and ashwagandha together. This gives you balanced support for both mental clarity and stress resilience. 
• You prefer a caffeine-free routine: AEON ONE™ delivers natural energy through whole-food nutrients and adaptogens without stimulants. This makes it suitable for those who are sensitive to caffeine or trying to cut back. 
• You are willing to invest in long-term health: At around 90 to 120 dollars per month, AEON ONE™ costs more than Four Sigmatic, but it also covers more categories. For many users, it can replace a greens powder, mushroom blend, adaptogen capsules, and probiotics, which may save money and reduce supplement clutter. 

Lifestyle Fit 

• For busy professionals: Four Sigmatic’s capsules are convenient to keep at a desk or carry in a bag. AEON ONE™ requires mixing but provides more comprehensive coverage. 
• For students and creatives: Four Sigmatic Focus Capsules offer quick cognitive support. AEON ONE™ supports both focus and stress balance, which may help during exam periods or high-pressure projects. 
• For health enthusiasts and biohackers: AEON ONE™ appeals to those who want an all-in-one foundation with advanced ingredients like shilajit, sea buckthorn, and multi-strain mushrooms. 
• For casual wellness users: Four Sigmatic offers an approachable way to add mushrooms into daily life, especially for people who already drink coffee and want to enhance it. 

The Bottom Line 

• Four Sigmatic is the better choice if you want affordable, targeted, and convenient mushroom support that you can use in capsules or coffee. 
• AEON ONE™ is the better choice if you want a premium, all-in-one daily ritual that combines mushrooms, adaptogens, and probiotics for full-spectrum support of focus, stress relief, gut health, and long-term resilience. 

In short: Four Sigmatic fits best as a specialist supplement, while AEON ONE™ is better as a comprehensive daily foundation. 

Also Read: How MUD\WTR™ and AEON ONE™ Tackle Caffeine Dependence Differently 

Conclusion 

Both AEON ONE™ and Four Sigmatic are strong players in the mushroom supplement space, but they serve different purposes. 

• Four Sigmatic specializes in targeted blends -ideal for users who want a product focused on either focus or calm, often at a lower price point. 
• AEON ONE™ provides a comprehensive, nature-first foundation with mushrooms, adaptogens, probiotics, and superfoods combined, appealing to those who want an all-in-one approach. 

If your goal is specific, affordable mushroom support, Four Sigmatic is a great choice. If your goal is long-term, full-spectrum daily resilience and energy without stimulants, AEON ONE™ may have the edge. 

Regulatory Caution: dietary supplement claims are not evaluated by the FDA the same way drugs are, and brands have faced regulatory scrutiny in the past for overstated health claims. Always check product Supplement Facts, third party test results, and consult a healthcare professional before starting new supplements. Look for third party testing and certificates of analysis when assessing quality. 

Frequently Asked Questions

Does Four Sigmatic contain caffeine? 

Some products (like mushroom coffee) contain caffeine, but their capsules and elixirs are generally caffeine-free. 

Which mushrooms are in AEON ONE™ vs Four Sigmatic? 

AEON ONE™ contains 8+ mushrooms, including lion’s mane, reishi, cordyceps, and chaga. Four Sigmatic products vary -lion’s mane and reishi are common. 

Which is more affordable? 

Four Sigmatic products average $10–$300. AEON ONE™ costs $89.95–$119.95/month (~$3.00/serving). 

Can you take AEON ONE™ and Four Sigmatic together? 

Yes, but it may be redundant. Many users choose one or the other based on whether they want an all-in-one formula or a targeted supplement. 

Are supplement claims regulated? 

Not in the same way as medications. Supplements like AEON ONE™ and Four Sigmatic fall under food regulation, which means companies can market them with limited oversight.